Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors

H Heitsch; A Wagner; B A Schölkens; K Wirth

doi:10.1016/s0960-894x(98)00736-7

Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors

Bioorg Med Chem Lett. 1999 Feb 8;9(3):327-32. doi: 10.1016/s0960-894x(98)00736-7.

Authors

H Heitsch¹, A Wagner, B A Schölkens, K Wirth

Affiliation

¹ Hoechst Marion Roussel GmbH, Frankfurt/Main, Germany. holger.heitsch@hmrag.com

PMID: 10091678
DOI: 10.1016/s0960-894x(98)00736-7

Abstract

The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations.

MeSH terms

Benzothiazoles
Bradykinin Receptor Antagonists*
Quinolines / chemical synthesis
Quinolines / chemistry
Quinolines / pharmacology*
Receptor, Bradykinin B2
Structure-Activity Relationship
Thiazoles / chemical synthesis
Thiazoles / chemistry
Thiazoles / pharmacology*

Substances

Benzothiazoles
Bradykinin Receptor Antagonists
Quinolines
Receptor, Bradykinin B2
Thiazoles
benzothiazole